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Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis.

The study measured the Free-radical oxidation products in the serum of 2 groups of patients: (a) 65 synovial effusions (b) 30 sera from normal subjects and 58 sera from patients with rheumatoid arthritis (RA). The concentration of free-radical oxidation products (detectable in 90% of synovial fluids) was higher in "inflammatory" versus in "degenerative" joint disease, and were significantly elevated in patients with RA compared to normal controls.