This study evaluated the effect of high protein (HP) content and high fiber (HF) content on satiation with 6 entire female dogs (2 Shetland Sheepdogs, 2 Brittany Spaniels, 2 Labrador Retrievers) undergoing a weight-loss program, and on palatability with 105 female dogs of different breeds and ages. Three diets (high protein [103 g/1,000 kcal] high fiber [60 g/1,000 kcal] [HPHF]; high protein [104 g/1,000 kcal] moderate fiber [35 g/1,000 kcal] [HP]; moderate protein [86 g/1,000 kcal] high fiber [87 g/1,000 kcal] [HF]) were used in 5 sequential voluntary food consumption trials and food preference tests. 3 hours after a restricted meal to satisfy 25% daily maintenance energy requirements, voluntary food intake was significantly lower in the HPHF group than in the HP and HF groups, with no significant differences between energy intake with the HP and HF diets. Concerning palatability, that of the HPHF diet was equivalent to the HP diet, and superior to the HF diet. Thus, the HPHF diet had a satiating effect and its palatability can enhance compliance of weight-loss programs.