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Major allergens in soybean and clinical significance of IgG4 antibodies investigated by IgE- and IgG4-immunoblotting with sera from soybean-sensitive patients.

This study investigates the allergenicity of soybean proteins, whose major allergens have not been well confirmed and the clinical significance of soybean-specific IgG4 in 30 human patients with soybean sensibility. They identified the soybean proteins that bound IgE or IgG4 in the whey fraction or the globulin fraction compared to controls. Strong reactivity to IgG4-binding proteins in patients with weak IgE reactivity suggested that soybean-specific IgG4 could act anaphylactically in patients with allergy to soybean.