The best way of supporting wound collagen production is provision of optimal host nutrition, ensuring adequate provision of calories and protein. Proline is a collagen precursor and is known to be actively imported into wounds; however, studies have shown that providing additional proline in the diet does not enhance collagen synthesis. In looking at other proline biosynthetic pathways, the arginine (ARG) --> ornithine (ORN) --> glutamic semialdehyde --> PRO pathway looks the most promising as supplementing the diet with arginine and ornithine have both been shown to enhance collagen deposition although it is unknown if this is due to increased proline production.